| ITF - W60 Rome, GA | 01/28 20:10 | 26 | [331] Irene Burillo Escorihuela v Despina Papamichail [277] | 6-2,6-1 | |
| ITF - W60 Rome, GA | 01/27 16:50 | 25 | [277] Despina Papamichail v Francesca Di Lorenzo [143] | 6-3,6-1 | |
| ITF - W25 Hamburg | 01/12 11:30 | 25 | [371] Marina B Ribera v Despina Papamichail [278] | 6-2,6-7,6-1 | |
| WTA - Abu Dhabi | 01/07 13:35 | 24 | [278] Despina Papamichail v Karolina Pliskova [6] | 2-6,6-7 | |
| WTA - Abu Dhabi | 01/06 06:00 | 19 | [278] Despina Papamichail v Zhaoxuan Yang [55] | 2-6,2-6 | |
| WTA - Abu Dhabi | 01/05 08:05 | 64 | [278] Despina Papamichail v Federica Di Sarra [320] | 2-6,7-5,6-1 | |
| ITF - W25 LPD Gran Canaria | 11/18 10:00 | 25 | [287] Amandine Hesse v Despina Papamichail [276] | 3-6,6-4,6-3 | |
| ITF - W25 Istanbul | 10/28 07:00 | 26 | [277] Despina Papamichail v Katarina Zavatska [116] | 2-6,5-7 | |
| ITF - W25 Istanbul | 10/27 08:50 | 25 | Despina Papamichail v Doga Akyurek | 6-3,6-2 | |
| ITF - W25 Istanbul | 10/26 07:00 | 54 | [277] Despina Papamichail v Ekaterina Kazionova [423] | 6-3,3-6,10-4 | |
| ITF - W25 Istanbul | 10/25 07:00 | 54 | Despina Papamichail v Betina Tokac | 6-1,6-1 | |
| ITF - W25 Reims | 10/18 10:15 | 54 | [278] Despina Papamichail v Francesca Jones [258] | 6-7,6-4,5-10 | |
| ITF - W25 Cherbourg | 10/11 15:40 | 54 | Lucie Wargnier v Despina Papamichail | 6-4,2-6,11-9 | |
| ITF - W25 Olimpia | 03/10 19:00 | 25 | [320] Francesca Jones v Despina Papamichail [264] | 6-2,6-1 | |
| ITF - W25 Antalya | 03/06 07:00 | 27 | [263] Despina Papamichail v Amina Anshba [352] | 3-6,1-6 | |
| ITF - W25 Antalya | 03/05 06:50 | 26 | [263] Despina Papamichail v Tena Lukas [262] | 2-6,6-2,6-3 | |
| ITF - W25 Antalya | 03/04 07:00 | 25 | Despina Papamichail v Ipek Oz | 7-6,6-2 | |
| ITF - W60 Cairo | 02/17 11:25 | 54 | [260] Despina Papamichail v Yidi Yang [461] | 3-6,6-2,8-10 | |
| ITF - W60 Cairo | 02/16 08:55 | 54 | Despina Papamichail v Merna Refaat | 6-0,6-2 | |
| ITF - W25 Trnava | 02/12 16:40 | 25 | [259] Despina Papamichail v Anna Kubareva [479] | 2-6,4-6 | |
| Fed Cup 2020 | 02/08 12:05 | - | [143] Viktoriya Tomova v Despina Papamichail [258] | 6-2,6-4 | |
| Fed Cup 2020 | 02/06 15:25 | 2 | [221] Julia Grabher v Despina Papamichail [258] | 1-6,6-4,7-5 | |
| Fed Cup 2020 | 02/05 16:30 | 1 | [22] Anett Kontaveit v Despina Papamichail [258] | 3-6,6-3,6-0 | |
| ITF - W25 Pune | 12/10 07:00 | 25 | [471] Shalimar Talbi v Despina Papamichail [267] | 6-4,3-6,6-1 | |
| ITF - W25 Solapur | 12/04 10:15 | 25 | Despina Papamichail v Emma Raducanu | 2-6,1-6 | |
| ITF - W25 Solarino | 11/27 09:00 | 25 | [286] Lara Salden v Despina Papamichail [263] | 3-6,6-4,6-1 | |
| ITF - W25 Naples | 11/20 14:00 | 25 | [311] Gabriela Talaba v Despina Papamichail [263] | 6-3,6-7,6-2 | |
| ITF - W25 Orlando | 11/13 15:00 | 25 | Despina Papamichail v Maria Mateas | 3-6,6-7 | |
| ITF W60 Colina | 11/05 18:20 | 25 | [407] Carolina Meligeni Rodrigues Alves v Despina Papamichail [260] | 4-6,7-5,6-3 | |
| ITF W60 Asuncion | 10/30 19:25 | 25 | Barbara Gatica v Despina Papamichail | 6-3,6-1 |
Despina Papamichail (Greek: Δέσποινα Παπαμιχαήλ; born 9 February 1993) is a Greek professional tennis player. She has a career-high singles ranking of world No. 147, reached on 20 June 2022. Her highest doubles ranking is No. 93, achieved on 4 December 2023. Papamichail has won two doubles titles on the WTA Challenger Tour as well as 15 singles and 37 doubles titles on the ITF Women's Circuit.
Playing for the Greece Fed Cup team, Papamichail has a win–loss record of 31–29 (as of May 2024).
In June 2021, Papamichail won the inaugural $60k Charleston Pro event by defeating Gabriela Cé, her first title above $25k level.
She made her WTA Tour main-draw debut 2021 at the WTA 500 event in Abu Dhabi.
At the 2023 United Cup, she started the season with a win over Isabella Shinikova.
Later, she qualified for the Pan Pacific Open and defeated lucky loser Sakura Hosogi.