Stadium: Seibert Stadium Round: 8
Home Manager: Chris Hatcher Away Manager: Frank Scelfo
| NCAAF | 2022/11/27 00:00 | Idaho v SE Louisiana | W | 42-45 |
| NCAAF | 2022/11/18 00:00 | SE Louisiana v Nicholls State | W | 40-17 |
| NCAAF | 2022/11/12 22:00 | Northwestern State v SE Louisiana | W | 7-23 |
| NCAAF | 2022/11/05 20:00 | SE Louisiana v Lamar | W | 47-31 |
| NCAAF | 2022/10/30 00:00 | SE Louisiana v McNeese State | W | 28-27 |
| NCAAF | 2022/10/22 18:00 | SE Louisiana v Jacksonville State | W | 31-14 |
| NCAAF | 2022/10/08 21:00 | Texas A&M-Commerce v SE Louisiana | L | 31-28 |
| NCAAF | 2022/10/01 23:00 | Murray State v SE Louisiana | W | 14-48 |
| NCAAF | 2022/11/19 18:00 | Mercer v Samford | W | 44-50 |
| NCAAF | 2022/11/12 18:30 | Samford v Tennessee Chattanooga | W | 35-24 |
| NCAAF | 2022/11/05 19:00 | VMI v Samford | W | 15-34 |
| NCAAF | 2022/10/29 18:00 | Samford v The Citadel | W | 38-3 |
| NCAAF | 2022/10/22 19:30 | Samford v East Tennessee State | W | 55-45 |
| NCAAF | 2022/10/08 17:00 | Wofford v Samford | W | 14-28 |
| NCAAF | 2022/10/01 18:00 | Samford v Furman | W | 34-27 |
| NCAAF | 2022/09/24 19:00 | Western Carolina v Samford | W | 12-35 |