Stadium: Strawberry Stadium Round: 1
Home Manager: Frank Scelfo Away Manager: Dean Hood
| NCAAF | 2022/09/24 21:00 | Eastern Illinois v Murray State | L | 35-21 |
| NCAAF | 2022/09/17 18:00 | Murray State v Ball State | L | 0-31 |
| NCAAF | 2022/09/10 23:00 | Jacksonville State v Murray State | L | 34-3 |
| NCAAF | 2022/09/04 00:00 | Murray State v Texas Tech | L | 10-63 |
| NCAAF | 2021/11/20 18:00 | Murray State v Eastern Illinois | W | 20-13 |
| NCAAF | 2021/11/13 19:00 | SE Missouri St v Murray State | W | 10-28 |
| NCAAF | 2021/11/06 18:00 | Tennessee Tech v Murray State | W | 27-32 |
| NCAAF | 2021/10/30 22:00 | Murray State v Tennessee State | L | 21-27 |
| NCAAF | 2022/09/24 23:00 | Incarnate Word v SE Louisiana | W | 35-41 |
| NCAAF | 2022/09/17 23:00 | Central Connecticut v SE Louisiana | W | 6-70 |
| NCAAF | 2022/09/10 22:00 | SE Louisiana v Florida Atlantic | L | 9-42 |
| NCAAF | 2022/09/03 23:00 | SE Louisiana v Lafayette | L | 7-24 |
| NCAAF | 2021/12/04 19:00 | SE Louisiana v James Madison | L | 20-59 |
| NCAAF | 2021/11/28 00:00 | Florida A&M v SE Louisiana | W | 14-38 |
| NCAAF | 2021/11/19 00:00 | Nicholls State v SE Louisiana | L | 45-42 |
| NCAAF | 2021/11/14 00:00 | Northwestern State v SE Louisiana | W | 28-56 |