Stadium: Strawberry Stadium Round: 1
Home Manager: Frank Scelfo Away Manager: Brad Laird
| NCAAF | 2021/10/23 20:00 | SE Louisiana v Northwestern State | L | 51-14 |
| NCAAF | 2021/03/14 00:00 | Northwestern State v SE Louisiana | L | 24-27 |
| NCAAF | 2019/09/28 23:00 | SE Louisiana v Northwestern State | L | 44-27 |
| NCAAF | 2018/09/30 00:00 | Northwestern State v SE Louisiana | L | 17-24 |
| NCAAF | 2017/09/30 23:30 | Northwestern State v SE Louisiana | L | 20-49 |
| NCAAF | 2021/11/06 20:00 | Houston Christian v Northwestern State | W | 24-28 |
| NCAAF | 2021/10/30 17:00 | Northwestern State v Nicholls State | L | 21-42 |
| NCAAF | 2021/10/23 20:00 | SE Louisiana v Northwestern State | L | 51-14 |
| NCAAF | 2021/10/16 20:00 | McNeese State v Northwestern State | L | 35-17 |
| NCAAF | 2021/10/09 23:00 | Northwestern State v Houston Christian | W | 21-17 |
| NCAAF | 2021/10/02 23:00 | Incarnate Word v Northwestern State | L | 38-27 |
| NCAAF | 2021/09/18 23:00 | Tennessee Martin v Northwestern State | L | 35-10 |
| NCAAF | 2021/09/11 23:00 | Northwestern State v Alcorn State | L | 10-13 |
| NCAAF | 2021/11/06 19:00 | SE Louisiana v Incarnate Word | L | 52-55 |
| NCAAF | 2021/10/30 23:00 | McNeese State v SE Louisiana | W | 20-23 |
| NCAAF | 2021/10/23 20:00 | SE Louisiana v Northwestern State | W | 51-14 |
| NCAAF | 2021/10/16 21:00 | Houston Christian v SE Louisiana | W | 24-61 |
| NCAAF | 2021/10/09 17:00 | SE Louisiana v Nicholls State | W | 58-48 |
| NCAAF | 2021/10/02 17:00 | SE Louisiana v McNeese State | W | 38-35 |
| NCAAF | 2021/09/18 16:00 | SE Louisiana v Central Connecticut | W | 56-10 |
| NCAAF | 2021/09/11 23:00 | SE Louisiana v Louisiana Tech | L | 42-45 |