Stadium: Eddie G. Robinson Memorial Stadium Round: 1
Home Manager: Broderick Fobbs Away Manager: Clarence McKinney
| NCAAF | 2019/11/02 19:00 | Texas Southern Tigers v Grambling State | L | 20-55 |
| NCAAF | 2018/10/13 23:00 | Grambling State v Texas Southern Tigers | L | 34-21 |
| NCAAF | 2017/10/28 19:00 | Grambling State v Texas Southern Tigers | L | 50-24 |
| NCAAF | 2021/10/09 21:00 | Southern v Texas Southern Tigers | W | 31-35 |
| NCAAF | 2021/10/02 19:00 | Texas Southern Tigers v North American Stallions | W | 69-0 |
| NCAAF | 2021/09/25 22:30 | Texas Southern Tigers v Rice | L | 34-48 |
| NCAAF | 2021/09/11 23:00 | Texas Southern Tigers v Baylor | L | 7-66 |
| NCAAF | 2021/09/05 00:00 | Prairie View v Texas Southern Tigers | L | 40-17 |
| NCAAF | 2021/03/21 00:30 | Southern v Texas Southern Tigers | L | 51-23 |
| NCAAF | 2021/03/07 01:00 | Texas Southern Tigers v Prairie View | L | 19-20 |
| NCAAF | 2019/11/23 21:00 | Texas Southern Tigers v Arkansas Pine Bluff | L | 13-45 |
| NCAAF | 2021/10/09 19:00 | Grambling State v Alcorn State | L | 20-24 |
| NCAAF | 2021/10/02 19:00 | Alabama v Grambling State | W | 28-37 |
| NCAAF | 2021/09/25 21:00 | Grambling State v Prairie View | L | 10-24 |
| NCAAF | 2021/09/18 23:00 | Grambling State v Houston | L | 0-45 |
| NCAAF | 2021/09/11 23:00 | Grambling State v Southern Mississippi | L | 0-37 |
| NCAAF | 2021/09/05 20:00 | Grambling State v Tennessee State | W | 16-10 |
| NCAAF | 2021/04/17 18:30 | Grambling State v Southern | L | 7-49 |
| NCAAF | 2021/03/20 17:00 | Arkansas Pine Bluff v Grambling State | L | 48-21 |