[93] Northwestern 23-30 Duke [77] 2021-09-18 20:00
Stadium: Brooks Field at Wallace Wade Stadium Round: 1
Home Manager: David Cutcliffe Away Manager: Pat Fitzgerald
Head to Head
| NCAAF | 2018/09/08 16:00 | Duke v Northwestern | L | 21-7 |
| NCAAF | 2017/09/09 16:00 | Northwestern v Duke | L | 17-41 |
| NCAAF | 2016/09/18 00:00 | Northwestern v Duke | W | 24-13 |
| NCAAF | 2015/09/19 16:30 | Duke v Northwestern | W | 10-19 |
| NCAAF | 2008/09/06 12:00 | Duke v Northwestern | W | 20-24 |
| NCAAF | 2007/09/15 12:00 | Northwestern v Duke | L | 14-20 |
| NCAAF | 2003/09/20 12:00 | Duke v Northwestern | W | 10-28 |
| NCAAF | 2002/09/14 12:00 | Northwestern v Duke | W | 26-21 |
Home History
| NCAAF | 2021/09/11 16:00 | Indiana State v Northwestern | W | 6-24 |
| NCAAF | 2021/09/04 01:00 | Michigan State v Northwestern | L | 38-21 |
| NCAAF | 2021/01/01 18:00 | Auburn v Northwestern | W | 19-35 |
| NCAAF | 2020/12/19 17:00 | Northwestern v Ohio State | L | 10-22 |
| NCAAF | 2020/12/12 17:00 | Illinois v Northwestern | W | 10-28 |
| NCAAF | 2020/11/28 20:30 | Northwestern v Michigan State | L | 20-29 |
| NCAAF | 2020/11/21 20:30 | Wisconsin v Northwestern | W | 7-17 |
| NCAAF | 2020/11/14 22:00 | Northwestern v Purdue | W | 27-20 |
Away History
| NCAAF | 2021/09/11 00:00 | North Carolina A&T v Duke | W | 17-45 |
| NCAAF | 2021/09/03 23:00 | Duke v Charlotte | L | 28-31 |
| NCAAF | 2020/12/12 21:00 | Duke v Florida State | L | 35-56 |
| NCAAF | 2020/12/06 01:00 | Miami Florida v Duke | L | 48-0 |
| NCAAF | 2020/11/29 00:00 | Duke v Georgia Tech | L | 33-56 |
| NCAAF | 2020/11/07 17:00 | North Carolina v Duke | L | 56-24 |
| NCAAF | 2020/10/31 23:00 | Charlotte v Duke | W | 19-53 |
| NCAAF | 2020/10/17 19:30 | Duke v NC State | L | 20-31 |