Stadium: Shell Energy Stadium Round: 1
Home Manager: Clarence McKinney Away Manager: Eric Dooley
| NCAAF | 2021/03/07 01:00 | Texas Southern Tigers v Prairie View | W | 19-20 |
| NCAAF | 2019/08/31 22:30 | Prairie View v Texas Southern Tigers | W | 44-23 |
| NCAAF FCS | 2018/11/24 19:00 | Texas Southern Tigers v Prairie View | W | 14-60 |
| NCAAF | 2017/11/26 00:00 | Texas Southern Tigers v Prairie View | W | 16-30 |
| NCAAF | 2021/04/17 20:00 | Prairie View v Arkansas Pine Bluff | L | 31-36 |
| NCAAF | 2021/03/13 21:00 | Prairie View v Grambling State | W | 17-10 |
| NCAAF | 2021/03/07 01:00 | Texas Southern Tigers v Prairie View | W | 19-20 |
| NCAAF | 2019/11/28 20:00 | Prairie View v Alabama State | W | 20-17 |
| NCAAF | 2019/11/16 20:00 | Prairie View v Edward Waters Tigers | W | 41-14 |
| NCAAF | 2019/11/09 20:00 | Arkansas Pine Bluff v Prairie View | W | 20-37 |
| NCAAF | 2019/10/24 23:30 | Jackson State v Prairie View | L | 38-35 |
| NCAAF | 2019/10/19 19:00 | Prairie View v Lynchburg Dragons | W | 51-0 |
| NCAAF | 2021/03/21 00:30 | Southern v Texas Southern Tigers | L | 51-23 |
| NCAAF | 2021/03/07 01:00 | Texas Southern Tigers v Prairie View | L | 19-20 |
| NCAAF | 2019/11/23 21:00 | Texas Southern Tigers v Arkansas Pine Bluff | L | 13-45 |
| NCAAF | 2019/11/09 20:00 | Alabama State v Texas Southern Tigers | L | 27-21 |
| NCAAF | 2019/11/02 19:00 | Texas Southern Tigers v Grambling State | L | 20-55 |
| NCAAF | 2019/10/26 19:00 | Texas Southern Tigers v Mississippi Valley State | L | 14-35 |
| NCAAF | 2019/10/19 19:00 | Southern v Texas Southern Tigers | L | 28-21 |
| NCAAF | 2019/10/12 19:00 | Texas Southern Tigers v Missouri S&t Miners | L | 20-23 |